Guillain-Barré Syndrome Research
Research on Guillain-Barré syndrome has been performed extensively since it was first described in 1916. Further research is ongoing to ensure advances in the diagnosis, treatment, and prognosis of patients with Guillain-Barré syndrome. On this page, several important research papers and ongoing studies are highlighted.
Ongoing Studies
International GBS Outcome Study

Follow-up; no more inclusions. Coordinated from the Erasmus UMC in Rotterdam.
 
GBS Mimics Study

Still including patients in the Netherlands. Coordinated from the Erasmus UMC in Rotterdam.
Featured Publication
Diagnosis and management of Guillain-Barré syndrome in ten steps

Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice.

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Guillain-Barré Syndrome Publications
General Reviews

Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barré syndrome. The Lancet. 2021;397(10280):1214-1228.

Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. The Lancet. 2016;388(10045):717-727.

Papri N, Islam Z, Leonhard SE, Mohammad QD, Endtz HP, Jacobs BC. Guillain-Barré syndrome in low-income and middle-income countries: challenges and prospects. Nature Reviews Neurology. 2021;17(5):285-296.
International GBS Outcome Study (IGOS)
Protocol
Protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré Syndrome

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Treatment

Current treatment practice of Guillain-Barré syndrome

Second IVIg course in Guillain-Barré syndrome with poor prognosis: the non-randomised ISID study

Intravenous immunoglobulin treatment for mild Guillain-Barré syndrome: an international observational study

Epidemiology

Regional variation of Guillain-Barré syndrome

Guillain-Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity

Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study

An International Perspective on Preceding Infections in Guillain-Barré Syndrome: The IGOS 1000-Cohort

Prognostic Models

Predicting Outcome in Guillain-Barré Syndrome

International Validation of the Erasmus Guillain-Barré Syndrome Respiratory Insufficiency Score

Modified Erasmus GBS Respiratory Insufficiency Score: a simplified clinical tool to predict the risk of mechanical ventilation in Guillain-Barré syndrome

Electrodiagnosis

Electrodiagnosis of Guillain-Barre syndrome in the International GBS Outcome Study: Differences in methods and reference values

Electrodiagnostic subtyping in Guillain-Barré syndrome: use of criteria in practice based on a survey study in IGOS

Use the publication links above to access the original research articles and study reports.